NEW YORK - APRIL 24: Writer Bill Simmons speaks at the panel and screening of "Beyond Playing The Field" during the 2010 Tribeca Film Festival at the School of Visual Arts Theater on April 24, 2010 in New York City. (Photo by Rob Loud/Getty Images for Tribeca Film Festival) *** Local Caption *** Bill Simmons

Bill Simmons tosses a scorching hot accusation at ESPN and its biggest loudmouth

Bill Simmons isn't holding back.

The 2nd Circuit Court of Appeals denied Tom Brady's appeal of his four-game suspension stemming from his alleged role in DeflateGate on Wednesday.

Related: What's next for Brady, and what it means for the NFL after DeflateGate suspension upheld

ESPN's resident talking head Stephen A. Smith slammed Brady in the aftermath, but it was former-ESPN employee, now HBO personality Bill Simmons who fired the most eye-opening shot:

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Simmons continued to weigh in on the Brady situation, taking aim at NFL commissioner Roger Goodell:

Brady's last option is to take his fight to the Supreme Court. We'll see how much longer this never-ending thriller that is DeflateGate goes.