DENVER, CO - NOVEMBER 29: Quarterback Tom Brady #12 of the New England Patriots and quarterback Jimmy Garoppolo #10 of the New England Patriots run onto the field before a game against the Denver Broncos at Sports Authority Field at Mile High on November 29, 2015 in Denver, Colorado. (Photo by Justin Edmonds/Getty Images)

What's next for Brady, and what it means for the NFL after DeflateGate suspension upheld

Brady has one last option.

Tom Brady's four-game suspension was upheld by the Federal appeals court on Wednesday, leaving the New England Patriots and the rest of the league pondering what happens next.

For Brady, it seems like a sure bet he'll take this all the way up to the Supreme Court:

As for the league, the Arizona Cardinals, Miami Dolphins, Houston Texans and Buffalo Bills will give the likely starter Jimmy Garoppolo a warm welcome to the NFL.

With just two years remaining on his deal, there's no better time than now than to see what the Eastern Illinois product is made of. Is he the heir apparent to Brady's Pats? Will he be trade bait later in the season, or will he command a Brock Osweiler-esque deal (four years, $72 million) in free agency two years from now? It all starts with Week 1 against the Cards and a fairly stiff list of opponents.

As for Brady, look out Cleveland Browns. When Touchdown Tom gets back on the field in Week 5, he'll ready to go, and should light up a porous Cleveland secondary. That one could get ugly in a hurry.